In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography

Barry Cense; Teresa C Chen; Boris Hyle Park; Mark C. Pierce; Johannes F. de Boer

doi:10.1117/12.477971

14 July 2003 In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography

Barry Cense, Teresa C Chen, Boris Hyle Park, Mark C. Pierce, Johannes F. de Boer

Author Affiliations +

Proceedings Volume 4951, Ophthalmic Technologies XIII; (2003) https://doi.org/10.1117/12.477971
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

We present in vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer (RNFL) by use of polarization-sensitive optical coherence tomography (PS-OCT). Because glaucoma causes nerve fiber layer damage, which may cause loss of retinal birefringence, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces real-time images of the human retina in vivo, co-registered with video images of the location of PS-OCT scans on the retina. Preliminary measurements of a healthy volunteer showed that the double-pass phase retardation per unit depth of the RNFL varies with location with values in between 0.18 and 0.37°/μm. A trend in the preliminary measurements shows that thicker nerve fiber layer tissue is more birefringent than thin nerve fiber layer tissue.

Citation Download Citation

Barry Cense, Teresa C Chen, Boris Hyle Park, Mark C. Pierce, and Johannes F. de Boer "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography", Proc. SPIE 4951, Ophthalmic Technologies XIII, (14 July 2003); https://doi.org/10.1117/12.477971

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