Optical heterodyne surface plasmon resonance biosensor

Chien Chou; Wen-chuan Kuo; Hsieh-Ting Wu

doi:10.1117/12.476721

1 July 2003 Optical heterodyne surface plasmon resonance biosensor

Chien Chou, Wen-chuan Kuo, Hsieh-Ting Wu

Proceedings Volume 4957, Optical Fibers and Sensors for Medical Applications III; (2003) https://doi.org/10.1117/12.476721
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

A novel optical heterodyne surface plasmon resonance (SPR) biosensor using Zeeman laser is proposed. There are two surface plasma waves (SPWs) being excited by two correlated P polarized waves in an SPR device of Kretschmann configuration. The two reflected P waves are optically heterodyned so that the amplitude of the heterodyned signal is proportional to the multiplication of two attenuated reflected P waves. The detection sensitivity and the dynamical range based on this amplitude sensitive method are enhanced. In the experiment, the kinetics between mouse IgG and anti-mouse IgG is obtained according to the sensograms of different concentrations of anti-mouse IgG. The detection sensitivity corresponding to 0.2 nM is achieved. In addition, a concentration of 5 ng/ml of protein G interacting with mouse IgG is measured successfully.

Citation Download Citation

Chien Chou, Wen-chuan Kuo, and Hsieh-Ting Wu "Optical heterodyne surface plasmon resonance biosensor", Proc. SPIE 4957, Optical Fibers and Sensors for Medical Applications III, (1 July 2003); https://doi.org/10.1117/12.476721

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KEYWORDS

Heterodyning

Biosensors

Sensors

Surface plasmons

Interfaces

Reflectivity

Wave plates

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