Study of the FMRI blood oxygen level dependent effect by near-infrared spectroscopy

Vladislav Toronov; Andrew Webb; Scott Walker; Rajarsi Gupta; Jee Hyun Choi; Enrico Gratton; Dennis M. Hueber

doi:10.1117/12.518770

13 October 2003 Study of the FMRI blood oxygen level dependent effect by near-infrared spectroscopy

Vladislav Toronov, Andrew Webb, Scott Walker, Rajarsi Gupta, Jee Hyun Choi, Enrico Gratton, Dennis M. Hueber

Proceedings Volume 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV; (2003) https://doi.org/10.1117/12.518770
Event: Saratov Fall Meeting 2002 Laser Physics and Photonics, Spectroscopy, and Molecular Modeling III; Coherent Optics of Ordered and Random Media III, 2002, Saratov, Russian Federation

Abstract

In order to study the behavior of cerebral physiological parameters and to further the understanding of the fMRI blood-oxygen-level-dependent (BOLD) effect, we have recorded simultaneously multi-source frequency-domain near-infrared and BOLD fMRI signals during motor functional activation in humans. From the near-infrared data we obtained information on the changes in cerebral blood volume and oxygenation. In order to relate our observations to changes in cerebral blood flow we employed the “balloon” model of cerebral perfusion. Our data showed that the deoxyhemoglobin concentration is the major factor determining the time course of the BOLD signal.

Citation Download Citation

Vladislav Toronov, Andrew Webb, Scott Walker, Rajarsi Gupta, Jee Hyun Choi, Enrico Gratton, and Dennis M. Hueber "Study of the FMRI blood oxygen level dependent effect by near-infrared spectroscopy", Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); https://doi.org/10.1117/12.518770

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