Improvement of photodynamic activity of aluminium sulphophthalocyanine due to biotinylation

Irina G. Meerovich; Victoria V. Jerdeva; Valentina M. Derkacheva; Gennadii A. Meerovich; Eugeny A. Lukyanets; Eugenia A. Kogan; Alexander P. Savitsky

doi:10.1117/12.518711

22 September 2003 Improvement of photodynamic activity of aluminium sulphophthalocyanine due to biotinylation

Irina G. Meerovich, Victoria V. Jerdeva, Valentina M. Derkacheva, Gennadii A. Meerovich, Eugeny A. Lukyanets, Eugenia A. Kogan, Alexander P. Savitsky

Author Affiliations +

Proceedings Volume 5149, Laser Applications in Medicine, Biology, and Environmental Science; (2003) https://doi.org/10.1117/12.518711
Event: International Conference on Lasers, Applications, and Technologies 2002, 2002, Moscow, Russian Federation

Abstract

The photodynamic activity of dibiotinylated aluminium sulphophthalocyanine in vitro and in vivo were studied. It was obtained that in vitro dibiotinylated aluminium sulphophthalocyanine provides the effective damage of small cell lung carcinoma OAT-75. In vivo dibiotinylated aluminium sulphophthalocyanine causes destruction of tumor (Erlich carcinoma), results in total necrosis of tumor tissue and expresses vascular damage (trombosis and destruction of vascular walls) even in concentration 0.25 mg/kg of a body weight.

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Irina G. Meerovich, Victoria V. Jerdeva, Valentina M. Derkacheva, Gennadii A. Meerovich, Eugeny A. Lukyanets, Eugenia A. Kogan, and Alexander P. Savitsky "Improvement of photodynamic activity of aluminium sulphophthalocyanine due to biotinylation", Proc. SPIE 5149, Laser Applications in Medicine, Biology, and Environmental Science, (22 September 2003); https://doi.org/10.1117/12.518711

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