Derivative spectrophotometric analysis of cerebrospinal fluid for the detection of a ruptured cerebral aneurysm

P. R. Bhadri; A. Majumder; C. J. Morgan M.D.; G. J. Pyne; M. Zuccarello M.D.; E. Jauch; K. R. Wagner; J. F. Clark; J. Caffery Jr.; Fred R. Beyette Jr.

doi:10.1117/12.508062

23 October 2003 Derivative spectrophotometric analysis of cerebrospinal fluid for the detection of a ruptured cerebral aneurysm

P. R. Bhadri, A. Majumder, C. J. Morgan M.D., G. J. Pyne, M. Zuccarello M.D., E. Jauch, K. R. Wagner, J. F. Clark, J. Caffery Jr., Fred R. Beyette Jr.

Author Affiliations +

Proceedings Volume 5202, Optical Information Systems; (2003) https://doi.org/10.1117/12.508062
Event: Optical Science and Technology, SPIE's 48th Annual Meeting, 2003, San Diego, California, United States

Abstract

A cerebral aneurysm is a weakened portion of an artery in the brain. When a cerebral aneurysm ruptures, a specific type of bleeding known as a subarachnoid hemorrhage (SAH) occurs. No test exists currently to screen people for the presence of an aneurysm. The diagnosis of a SAH is made after an aneurysm ruptures, and the literature indicates that nearly one-third of patients with a SAH are initially misdiagnosed and subjected to the risks associated with aneurysm re-rupture. For those individuals with a suspected SAH, a computerized tomography (CT) scan of the brain usually demonstrates evidence of the bleeding. However, in a considerable portion of people, the CT scan is unable to detect the blood that has escaped from the blood vessel. For circumstances when a SAH is suspected despite a normal CT scan, physicians make the diagnosis of SAH by performing a spinal tap. A spinal tap uses a needle to sample the cerebrospinal fluid (CSF) collected from the patient’s back; CSF is tainted with blood after the aneurysm ruptures. To distinguish between a common headache and a SAH, a fast and an effective solution is required. We describe the development of an effective detection system integrating hardware and a powerful software interface solution. Briefly, CSF from the patient is aspirated and excited with an appropriate wavelength of light. The software employs spectrophotometric analysis of the output spectra and lays the foundation for the development of portable and user-friendly equipment for detection of a ruptured cerebral aneurysm.

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P. R. Bhadri, A. Majumder, C. J. Morgan M.D., G. J. Pyne, M. Zuccarello M.D., E. Jauch, K. R. Wagner, J. F. Clark, J. Caffery Jr., and Fred R. Beyette Jr. "Derivative spectrophotometric analysis of cerebrospinal fluid for the detection of a ruptured cerebral aneurysm", Proc. SPIE 5202, Optical Information Systems, (23 October 2003); https://doi.org/10.1117/12.508062

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