Preliminary study of diagnostic spectroscopic imaging for nasopharyngeal carcinoma

Buhong Li; Shusen Xie; Xiaodong Zhang; Depin Li

doi:10.1117/12.546159

8 December 2003 Preliminary study of diagnostic spectroscopic imaging for nasopharyngeal carcinoma

Buhong Li, Shusen Xie, Xiaodong Zhang, Depin Li

Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546159
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China

Abstract

The optical biopsy system for nasopharyngeal carcinoma based on the technique of laser-induced exogenous fluorescence has been successful developed. Ar⁺ laser was selected as the excitation light source based on the measurement of the Emission-Excitation Matrix of Hematoporphyrin Monomethyl Ether. Tissue-simulating optical phantoms diluted with different concentration of HMME were used to simulated nasopharyngeal carcinoma lesions in the performance test for the drug-fluorescence optical biopsy system, especially for the comparison of fluorescence image contrast between the excitation wavelength of 488nm and 514.5nm, respectively. Experimental results show that the fluorescence image contrast of simulated nasopharyngeal carcinoma lesions excited by the light at the wavelength of 488nm is about three fold higher than that at 514.5nm, and the sensitivity and resolution of the fluorescence and reflection twilight image can satisfy the needs for clinical diagnosis and localization.

Citation Download Citation

Buhong Li, Shusen Xie, Xiaodong Zhang, and Depin Li "Preliminary study of diagnostic spectroscopic imaging for nasopharyngeal carcinoma", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); https://doi.org/10.1117/12.546159

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