Health monitoring of biomaterials from molecular fingerprints

Reiner Salzer; Gerald Steiner; Christoph Krafft; Cordelia A. Zimmerer; Sibel Tunc

doi:10.1117/12.538374

21 July 2004 Health monitoring of biomaterials from molecular fingerprints

Reiner Salzer, Gerald Steiner, Christoph Krafft, Cordelia A. Zimmerer, Sibel Tunc

Proceedings Volume 5394, Health Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems III; (2004) https://doi.org/10.1117/12.538374
Event: NDE for Health Monitoring and Diagnostics, 2004, San Diego, CA, United States

Abstract

Structural changes in proteins may result in interactions between proteins themselves or between proteins and other biomolecules, which in turn may introduce deterioration of the health state of the system, might it be biological or biomimetic. The initial structural changes in proteins can not be observed by established methods of material analysis like X-ray diffraction or NMR spectroscopy, because proteins in biological cells have an extremely low abundance and are in the non-crystalline state. An obvious gap exists between sequencing techniques for amino acids and the molecular understanding of the functional properties of a particular protein. Vibrational spectroscopic methods offer the potential of fast and accurate characterization of essential supramolecular properties in the native state of the biomaterial. Imaging techniques recently became available for both FTIR and Raman spectroscopy. Here we report on the utilization of the enormous information content of FTIR and Raman spectra for health monitoring in engineering and medicine.

Citation Download Citation

Reiner Salzer, Gerald Steiner, Christoph Krafft, Cordelia A. Zimmerer, and Sibel Tunc "Health monitoring of biomaterials from molecular fingerprints", Proc. SPIE 5394, Health Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems III, (21 July 2004); https://doi.org/10.1117/12.538374

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available