Photochemical surface modification method for fibrin free intraocular lens

Yuji Sato; Nobuhiro Sato; Masataka Murahara

doi:10.1117/12.588914

18 April 2005 Photochemical surface modification method for fibrin free intraocular lens

Yuji Sato, Nobuhiro Sato, Masataka Murahara

Proceedings Volume 5688, Ophthalmic Technologies XV; (2005) https://doi.org/10.1117/12.588914
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

The dot patterned hydrophilic and hydrophobic groups were photo-chemically substituted in minute pattern on the polymethylmethacrylate [PMMA] intraocular lens [IOL] by the Xe₂ excimer lamp and the ArF excimer laser; consequently, the IOL that is free from fibrin has been developed. PMMA has been used as an intraocular lens IOL because of its high transmittance in the visible region and superb mechanical modifiability. However, protein and fat are stuck onto the lens surface after a long-term insertion, where cells proliferate; which causes the surface to get opaque, namely after-cataract. Firstly, the IOL was irradiated with Xe₂ excimer lamp in the presence of perfluoropolyether [PFPE] to be hydrophobic. By the photochemical reaction, the CF₃ functional groups were substituted on the IOL surface. In order to substitute hydrophilic groups in matrix-form on the surface, the ArF laser light was then irradiated on the hydrophobic surface in the presence of water through the 50mm f dot-patterned negative mask and the lens to project the reduced pattern. With this selective photochemical surface modification, the hydrophilic and hydrophobic groups were arrayed alternately on the sample surface. The modified IOL was soaked in fibrin [FIB] water solution, and the fibrin-sticking rate was measured by infrared spectroscopy [FT-IR]. The lower fibrin-sticking rate of the IOL surface was achieved by the hydrophobic and hydrophilic micro domain structures. Furthermore, it was confirmed that the fibrin-sticking rate decreased as the OH group interval was narrowed. The modified surface with the 20 mm f domains with hydrophilic and hydrophobic was lowest in fibrin sticking.

Citation Download Citation

Yuji Sato, Nobuhiro Sato, and Masataka Murahara "Photochemical surface modification method for fibrin free intraocular lens", Proc. SPIE 5688, Ophthalmic Technologies XV, (18 April 2005); https://doi.org/10.1117/12.588914

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available