Frequency domain tomography in small animals with the equation of radiative transfer

Kui Ren; Bryte Moa-Anderson; Guillaume Bal; Xuejun Gu; Andreas H. Hielscher

doi:10.1117/12.591113

28 April 2005 Frequency domain tomography in small animals with the equation of radiative transfer

Kui Ren, Bryte Moa-Anderson, Guillaume Bal, Xuejun Gu, Andreas H. Hielscher

Proceedings Volume 5693, Optical Tomography and Spectroscopy of Tissue VI; (2005) https://doi.org/10.1117/12.591113
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

We have developed a model-based iterative image reconstruction scheme based on the equation of radiative transfer in the frequency domain for the applications in small animal optical tomographic imaging. To test the utility of such a code in small animal imaging we have furthermore developed a numerical phantom of a mouse. In simulation studies using this and other phantoms, we found that to make truly use of phase information in the reconstruction process modulation frequencies well above 100 MHz are necessary. Only at these higher frequencies the phase shifts introduced by the lesions of interest are large enough to be measured. For smaller frequencies no substantial improvements over steady-state systems are achieved in small geometries typical for small animal imaging.

Citation Download Citation

Kui Ren, Bryte Moa-Anderson, Guillaume Bal, Xuejun Gu, and Andreas H. Hielscher "Frequency domain tomography in small animals with the equation of radiative transfer", Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); https://doi.org/10.1117/12.591113

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