Spontaneous oscillations in mechanosensory hair bundles

Bjorn Nadrowski; Pascal Martin; Frank Julicher

doi:10.1117/12.611198

23 May 2005 Spontaneous oscillations in mechanosensory hair bundles (Keynote Address)

Bjorn Nadrowski, Pascal Martin, Frank Julicher

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Proceedings Volume 5841, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III; (2005) https://doi.org/10.1117/12.611198
Event: SPIE Third International Symposium on Fluctuations and Noise, 2005, Austin, Texas, United States

Abstract

The ear relies on nonlinear amplification to enhance its sensitivity and frequency selectivity. It has been suggested that this active process results from dynamical systems which oscillate spontaneously. In the bullfrog sacculus, hair bundles, which are the mechanosensitive elements of sensory hair cells display noisy oscillations. These oscillations can be described in a simple model which takes into account the properties of mechanosensitive ion channels coupled to motor proteins which are regulated by inflowing Ca²⁺ ions. The role of fluctuations can be studied by adding random forcing terms with characteristic amplitudes that result from the number and properties of ion channels and motor molecules. This description can account quantitatively for the experimentally measured linear and nonlinear response functions and reveals the relevance of fluctuations for signal detection.

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Bjorn Nadrowski, Pascal Martin, and Frank Julicher "Spontaneous oscillations in mechanosensory hair bundles (Keynote Address)", Proc. SPIE 5841, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III, (23 May 2005); https://doi.org/10.1117/12.611198

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KEYWORDS

Calcium

Ear

Ion channels

Stochastic processes

Molecules

Nonlinear response

Complex systems

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