Investigation of human biomarkers in exhaled breath by laser photoacoustic spectroscopy

D. C. Dumitras; G. Giubileo; A. Puiu

doi:10.1117/12.633696

7 June 2005 Investigation of human biomarkers in exhaled breath by laser photoacoustic spectroscopy

D. C. Dumitras, G. Giubileo, A. Puiu

Proceedings Volume 5850, Advanced Laser Technologies 2004; (2005) https://doi.org/10.1117/12.633696
Event: Advanced Laser Technologies 2004, 2004, Rome and Frascati, Italy

Abstract

The paper underlines the importance of breath tests in medicine and the potential of laser techniques to measure in-vivo and in real time human biomarkers. The presence of trace amounts of gases or the metabolites of a precursor in exhaled air could be linked to kidney or liver malfunction, asthma, diabetes, cancer, ulcers or neurological disorders. The measurement of some human biomarkers (ethylene, ammonia), based on laser photoacoustic spectroscopy methods, insure very high sensitivity and selectivity. The technical characteristics of this instrument were measured to determine the detection limits (sub-ppb for ethylene). The results of ethylene release following lipid peroxidation initiated by X-ray irradiation or ingestion of radioactive compounds are presented. The possibility to extend this technique for measurement of breath ammonia levels in patients with end-stage renal disease while they are undergoing hemodialysis is discussed.

Citation Download Citation

D. C. Dumitras, G. Giubileo, and A. Puiu "Investigation of human biomarkers in exhaled breath by laser photoacoustic spectroscopy", Proc. SPIE 5850, Advanced Laser Technologies 2004, (7 June 2005); https://doi.org/10.1117/12.633696

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