Photoacoustic spectroscopy application in diffusion examinations

Jerzy Bodzenta; Bui Duc Hanh; Anna Kazmierczak; Reinhard H. H. Neubert; Siegfrid Wartewig

doi:10.1117/12.621858

29 September 2005 Photoacoustic spectroscopy application in diffusion examinations

Jerzy Bodzenta, Bui Duc Hanh, Anna Kazmierczak, Reinhard H. H. Neubert, Siegfrid Wartewig

Proceedings Volume 5953, Acousto-optics and Photoacoustics; 595309 (2005) https://doi.org/10.1117/12.621858
Event: Congress on Optics and Optoelectronics, 2005, Warsaw, Poland

Abstract

Based on Fick's second law the problem of drug diffusion into a membrane was solved. Spatial and time dependent distribution of the drug in the membrane was described analytically. Comparison of obtained solution with experimental results from infrared attenuated total reflectance studies of dithranol diffusion into the dodecanol-collodion membrane confirmed correctness of the theory. Based on a model describing the concentration of diffusing matter it was possible to calculate numerically the photoacoustic signal arising when the membrane was illuminated by modulated light. Detailed numerical analysis showed that photoacoustic spectroscopy (PAS) can be used in experimental investigation of diffusion, but some limitations connected with optical parameters of diffusing matter and the membrane must be taken into account. Proposed mathematical model was used for interpretation of experimental data from "classical" PAS measurement in UV range and step-scan Fourier-transform infrared PAS. Experiments were carried out for diffusion of: dithranol, ketoconazole and methoxalen. Using a multiparameter fitting procedure one has determined diffusion coefficient of enumerated drugs in dodecanol-collodion membrane. Obtained results confirmed usability of PAS technique for studies of diffusion processes.

Citation Download Citation

Jerzy Bodzenta, Bui Duc Hanh, Anna Kazmierczak, Reinhard H. H. Neubert, and Siegfrid Wartewig "Photoacoustic spectroscopy application in diffusion examinations", Proc. SPIE 5953, Acousto-optics and Photoacoustics, 595309 (29 September 2005); https://doi.org/10.1117/12.621858

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