Evaluation of photosensitizers singlet oxygen production for photodynamic therapy applications using time resolved thermal lens

Lorenzo Echevarria; Luis Rodríguez; Aristides Marcano; Omar Estrada; Mary Salazar; Felipe Quintero

doi:10.1117/12.629331

21 November 2005 Evaluation of photosensitizers singlet oxygen production for photodynamic therapy applications using time resolved thermal lens

Lorenzo Echevarria, Luis Rodríguez, Aristides Marcano, Omar Estrada, Mary Salazar, Felipe Quintero

Author Affiliations +

Proceedings Volume 6009, Optical Methods in Drug Discovery and Development; 60090K (2005) https://doi.org/10.1117/12.629331
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

We report on the optical characterization and measurement of oxygen singlet quantum yield of Chlorophyll and Chlorin e₆ in water-ethanol mixtures by direct observation of thermal relaxation using time resolved thermal lens method. The analysis of the time-resolved curve allows the determination of the quantum yield of singlet oxygen formation. The quantum yield is deduced from the relative magnitudes of the fast and slow components.

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Lorenzo Echevarria, Luis Rodríguez, Aristides Marcano, Omar Estrada, Mary Salazar, and Felipe Quintero "Evaluation of photosensitizers singlet oxygen production for photodynamic therapy applications using time resolved thermal lens", Proc. SPIE 6009, Optical Methods in Drug Discovery and Development, 60090K (21 November 2005); https://doi.org/10.1117/12.629331

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