A fractal analysis of pathogen detection by biosensors

Atul M. Doke; Ajit Sadana

doi:10.1117/12.664721

19 May 2006 A fractal analysis of pathogen detection by biosensors

Atul M. Doke, Ajit Sadana

Proceedings Volume 6218, Chemical and Biological Sensing VII; 62180Q (2006) https://doi.org/10.1117/12.664721
Event: Defense and Security Symposium, 2006, Orlando (Kissimmee), Florida, United States

Abstract

A fractal analysis is presented for the detection of pathogens such as Franscisela tularensis, and Yersinia pestis (the bacterium that causes plague) using a CANARY (cellular analysis and notification of antigens risks and yields) biosensor (Rider et al., 2003). In general, the binding and dissociation rate coefficients may be adequately described by either a single- or a dual-fractal analysis. An attempt is made to relate the binding rate coefficient to the degree of heterogeneity (fractal dimension value) present on the biosensor surface. Binding and dissociation rate coefficient values obtained are presented. The kinetics aspects along with the affinity values presented are of interest, and should along with the rate coefficients presented for the binding and the dissociation phase be of significant interest in help designing better biosensors for an application area that is bound to gain increasing importance in the future.

Citation Download Citation

Atul M. Doke and Ajit Sadana "A fractal analysis of pathogen detection by biosensors", Proc. SPIE 6218, Chemical and Biological Sensing VII, 62180Q (19 May 2006); https://doi.org/10.1117/12.664721

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