Photodynamic therapy (PDT) using intratumoral injection of the 5- aminolevulinic acid (5-ALA) for the treatment of eye cancer in cattle

Raduan Hage D.V.M.; Geraldo Mancilha D.V.M.; Renato Amaro Zângaro M.D.; Egberto Munin; Hélio Plapler M.D.

doi:10.1117/12.701316

28 February 2007 Photodynamic Therapy (PDT) using intratumoral injection of the 5- aminolevulinic acid (5-ALA) for the treatment of eye cancer in cattle

Raduan Hage D.V.M., Geraldo Mancilha D.V.M., Renato Amaro Zângaro M.D., Egberto Munin, Hélio Plapler M.D.

Author Affiliations +

Proceedings Volume 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI; 64271C (2007) https://doi.org/10.1117/12.701316
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

A six-year old Holstein cow with an eye cancer (ocular squamous cell carcinoma) involving the third eyelid and conjunctiva was submitted to photodynamic therapy using intratumoral 20% aminolevulinic acid (5-ALA - Aldrich Chemical Company, Milwaukee, USA) and a light emitting diode (LED - VET LED - MMOptics^(R)) with wavelength between 600 and 700 nm, 2 cm diameter circular light beam, power of 150 mW, light dose of 50 J/cm² as a source of irradiation. Fifteen days after the experimental procedure we observed about 50% tumor reduction and complete remission after 3 months. Relapse was not observed up to 12 months after the treatment. Although the study only includes one animal not allowing definite conclusions, it indicates that PDT represents a safe and technically feasible approach in the treatment of eye cancer in cattle.

Citation Download Citation

Raduan Hage D.V.M., Geraldo Mancilha D.V.M., Renato Amaro Zângaro M.D., Egberto Munin, and Hélio Plapler M.D. "Photodynamic Therapy (PDT) using intratumoral injection of the 5- aminolevulinic acid (5-ALA) for the treatment of eye cancer in cattle", Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64271C (28 February 2007); https://doi.org/10.1117/12.701316

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