Evaluation of a fiber probe coupled with half ball lens for depth-resolved fluorescence measurements

Franck Jaillon; Wei Zheng; Zhiwei Huang

doi:10.1117/12.762177

12 February 2008 Evaluation of a fiber probe coupled with half ball lens for depth-resolved fluorescence measurements

Franck Jaillon, Wei Zheng, Zhiwei Huang

Proceedings Volume 6849, Design and Quality for Biomedical Technologies; 68490E (2008) https://doi.org/10.1117/12.762177
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

The association of a beveled collection fiber with a half ball lens is here simulated in order to illustrate the enhancement brought by this simple method in depth resolved measurements, the latter being of major importance in the study of epithelial tissues. Indeed, in order to follow the carcinogenesis stage by a non invasive technique such as fluorescence or Raman spectroscopy, it is valuable to be able to discriminate the depth origin of the detected signal. The proposed probe design consists in a beveled collection fiber positioned on the center of the half ball lens flat surface with an off-axis excitation flat fiber. Depending on the bevel angle of the collection fiber, discrimination between the epithelial and the stromal layer can be realized.

Citation Download Citation

Franck Jaillon, Wei Zheng, and Zhiwei Huang "Evaluation of a fiber probe coupled with half ball lens for depth-resolved fluorescence measurements", Proc. SPIE 6849, Design and Quality for Biomedical Technologies, 68490E (12 February 2008); https://doi.org/10.1117/12.762177

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