The wavelength-dependent characteristic of the floating-reference point in the non-invasive glucose sensing

Rong Liu; Wenliang Chen; Yue Yang; Yu Li; Kexin Xu

doi:10.1117/12.762156

22 February 2008 The wavelength-dependent characteristic of the floating-reference point in the non-invasive glucose sensing

Rong Liu, Wenliang Chen, Yue Yang, Yu Li, Kexin Xu

Author Affiliations +

Proceedings Volume 6863, Optical Diagnostics and Sensing VIII; 68630R (2008) https://doi.org/10.1117/12.762156
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

In the noninvasive blood glucose sensing using near-infrared spectroscopy, the physiological noise was one of the biggest challenges. In order to efficiently reduce the influence of the physiological background variations on the diffuse reflectance spectra, the floating-reference method was used by differentially processing two signals from reference point and measuring point. In this paper, the wavelength-dependent characteristic of the floating-reference point was discussed by simulation and primary experiment. First, the wavelength-dependent characteristic of intralipid- 5% solution was investigated in the wavelength range of 1300-1600nm. And source-detector distance for reference point in the wavelength of 1300nm was conducted by different concentration of scatter media including 2%, 5% and 10% intralipid solution. Then the single-layer and three layers skin model were built to investigate the wavelength characteristic of reference point. The water displacement coefficients and relative large change in glucose concentration were considered in the simulation. Finally, the primary experiment of intralipid model was conducted to validate the wavelength dependence of reference point. The result showed that, the floating reference will not exist in the strong absorption region (near 1450nm) and the region where the change of absorption coefficient is positive (high than 1525nm) due to the corporate influence of scattering and absorption coefficient. And the wavelength-dependent characteristic is consistent for intralipid solution and the skin model.

Citation Download Citation

Rong Liu, Wenliang Chen, Yue Yang, Yu Li, and Kexin Xu "The wavelength-dependent characteristic of the floating-reference point in the non-invasive glucose sensing", Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630R (22 February 2008); https://doi.org/10.1117/12.762156

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available