Photodynamic detection in visualisation of cutaneous and oral mucosa premalignant and malignant lesions: two clinical cases

Kamil Jurczyszyn; Piotr Ziólkowski; Beata Osiecka; Hanna Gerber; Magdalena Dziedzic

doi:10.1117/12.817984

18 November 2008 Photodynamic detection in visualisation of cutaneous and oral mucosa premalignant and malignant lesions: two clinical cases

Kamil Jurczyszyn, Piotr Ziólkowski, Beata Osiecka, Hanna Gerber, Magdalena Dziedzic

Author Affiliations +

Proceedings Volume 7138, Photonics, Devices, and Systems IV; 71380K (2008) https://doi.org/10.1117/12.817984
Event: Photonics, Devices, and Systems IV, 2008, Prague, Czech Republic

Abstract

Photodynamic diagnosis (PDD) is promising method of visualisation of premalignant and malignant lesions. PDD is consisted of two main agents: special chemical compound which is called photosensitizer and light. Photosensitizer has affinity to fast proliferating cells such as pre- or malignant. During light irradiation (with proper wavelength - corresponding to absorption peak of photosensitizer) photosensitizer gains energy and passes into excited singlet state S₁. Returning to basic singlet state S_n, leads to fluorescence. Due to difference between concentration of photosensitizer in lesion and normal tissue it is possible to obtain high contrast image of lesion. Case #1: 53 years old woman with basal cell carcinoma (BCC) in nasal region; 20% delta-aminolevulinic acid as a precursor of photosensitizer on eucerin base was used. Case #2: 57 years old woman with multifocal oral leukoplakia on cheek mucosa and tongue; 2% chlorophyll gel as photosesitizer was used. All photographs were taken in white light without any filter and in blue and UV light with orange filter: in both cases the total area of the lesions appeared to be larger than it has been clinically observed. Thus, the PDD might be helpful in evaluation of margins of surgical excision of such lesions.

Citation Download Citation

Kamil Jurczyszyn, Piotr Ziólkowski, Beata Osiecka, Hanna Gerber, and Magdalena Dziedzic "Photodynamic detection in visualisation of cutaneous and oral mucosa premalignant and malignant lesions: two clinical cases", Proc. SPIE 7138, Photonics, Devices, and Systems IV, 71380K (18 November 2008); https://doi.org/10.1117/12.817984

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