Nanoparticles for enhanced contrast optical coherence tomography

César D. Maule; Pedro Quaresma; Patrícia A. Carvalho; Pedro Jorge; Eulália Pereira; Carla C. Rosa

doi:10.1117/12.818690

30 December 2008 Nanoparticles for enhanced contrast optical coherence tomography

César D. Maule, Pedro Quaresma, Patrícia A. Carvalho, Pedro Jorge, Eulália Pereira, Carla C. Rosa

Proceedings Volume 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics; 71390V (2008) https://doi.org/10.1117/12.818690
Event: 1st Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics, 2008, Canterbury, United Kingdom

Abstract

Recently the area of bioimaging has benefited from new types of image enhancing agents such as quantum dots, carbon nanotubes and other nanoparticles. Cellular or even molecular level resolution has been achieved with different techniques during these last years (i.a. Fluorescence microscopy, PET/CT scan, AFM). Optical Coherence Tomography (OCT) as an imaging technique should also profit from newly developed probes. In this work we explored the tunable properties of different types of nanoparticles as contrast enhancers in OCT applications. We mainly studied the development and characteristics of metallic nanoparticles with tunable properties: gold nanoshells made of a silica core coated with a gold shell. Nanoshell and nanoparticles processing techniques are discussed, as well as their optimization for designing particles with specific absorption and scattering characteristics, and its use in OCT imaging.

Citation Download Citation

César D. Maule, Pedro Quaresma, Patrícia A. Carvalho, Pedro Jorge, Eulália Pereira, and Carla C. Rosa "Nanoparticles for enhanced contrast optical coherence tomography", Proc. SPIE 7139, 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics, 71390V (30 December 2008); https://doi.org/10.1117/12.818690

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