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This work focuses on the development of a proof-of-concept optical sensor design that incorporates an
amine-functionalized polyacrylamide hydrogel into a 1D porous silicon (PSi) photonic crystal. The PSi
acts as both a template and a transducer capable of detecting morphological and dielectric changes in the
incorporated hydrogel structure. Free radical copolymerization of acrylamide (AAm) and N-(3-
aminopropyl)-methacrylamide (NA) monomers was utilized to form copolymer chains with a controlled
concentration of nucleophilic amine moieties. These amine groups facilitated chemical cross-linking of the
copolymer chain to generate hydrogel networks. A molar fraction of >2 mol% of NA monomer was needed
to facilitate a visibly gelatinous hydrogel in a 5 wt% polymer solution. Addition of sodium formate (chain
transfer agent) during copolymer synthesis facilitated decreased copolymer chain length and improved
infiltration of the copolymer into the p-type PSi mesoporous sensor (pore diameters ~20-30 nm).
Controlled cross-linking of the copolymer chains was completed with using glutaraldehyde, as a model
system, to form a hydrogel network that could be optically monitored by the incorporated PSi sensor. These
results lay foundation for extending this versatile methodology towards the design of an affinity based
complimentary target-probe system to create a hybrid target-responsive hydrogel-PSi chemical sensor.
Lisa M. Bonanno andLisa A. DeLouise
"Design of a hybrid amine functionalized polyacrylamide hydrogel-porous silicon optical sensor", Proc. SPIE 7167, Frontiers in Pathogen Detection: From Nanosensors to Systems, 71670F (19 February 2009); https://doi.org/10.1117/12.809201
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Lisa M. Bonanno, Lisa A. DeLouise, "Design of a hybrid amine functionalized polyacrylamide hydrogel-porous silicon optical sensor," Proc. SPIE 7167, Frontiers in Pathogen Detection: From Nanosensors to Systems, 71670F (19 February 2009); https://doi.org/10.1117/12.809201