Effect of spontaneous diffusion in micro/nanoporous chemically crosslinked poly (N-vinyl imidazole) gel on the conformational changes of acetylcholine

Evgenia Vaganova; Ines F. Pierola; Haim Ovadia; Sergey E. Lyshevski; Shlomo Yitzchaik

doi:10.1117/12.809083

24 February 2009 Effect of spontaneous diffusion in micro/nanoporous chemically crosslinked poly (N-vinyl imidazole) gel on the conformational changes of acetylcholine

Evgenia Vaganova, Ines F. Pierola, Haim Ovadia, Sergey E. Lyshevski, Shlomo Yitzchaik

Author Affiliations +

Proceedings Volume 7185, Single Molecule Spectroscopy and Imaging II; 718516 (2009) https://doi.org/10.1117/12.809083
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Interdependent structural properties such as molecular conformation, flexibility and charge redistribution control the intermolecular interactions of acetylcholine (ACh) with adjacent molecules. This paper reports the results of an investigation of the effect of the diffusion of ACh through a nano/microporous poly (N-vinylimidazole) (PVI) gel on its structural properties, namely on changes in its conformation. To investigate the conformational changes of ACh during spontaneous diffusion through the gel, the fluorescence lifetime of the label molecule - fluorescein - was monitored. To clarify the results, analogous experiments were conducted with nicotinic acid and dopamine. In contrast to the nicotinic acid and dopamine, ACh can play the role of a regulator in molecular transport.

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Evgenia Vaganova, Ines F. Pierola, Haim Ovadia, Sergey E. Lyshevski, and Shlomo Yitzchaik "Effect of spontaneous diffusion in micro/nanoporous chemically crosslinked poly (N-vinyl imidazole) gel on the conformational changes of acetylcholine", Proc. SPIE 7185, Single Molecule Spectroscopy and Imaging II, 718516 (24 February 2009); https://doi.org/10.1117/12.809083

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