Optimizing Fourier-domain angle resolved low coherence interferometry for clinical use

Neil G. Terry; Yizheng Zhu; Matthew Rinehart; Adam Wax

doi:10.1117/12.808021

24 February 2009 Optimizing Fourier-domain angle resolved low coherence interferometry for clinical use

Neil G. Terry, Yizheng Zhu, Matthew Rinehart, Adam Wax

Proceedings Volume 7187, Biomedical Applications of Light Scattering III; 71870W (2009) https://doi.org/10.1117/12.808021
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Methods for the optimization of a/LCI for clinical use are presented. First, the use of the T-matrix light scattering model to simulate scattering from spheroidal particles is presented as a more appropriate simulation of cell nuclei scattering than the previously used Mie theory. In addition, the use of a broadband light source with a bandwidth greater than 50nm similar to those utilized in OCT applications is demonstrated. Accurate sizing of scatterers in tissue phantoms containing stretched and unstretched polystyrene microspheres along with measurements of unstretched polystyrene microspheres in solution are presented, demonstrating advances in system performance and design. In addition, preliminary human in vivo esophageal tissue data are presented.

Citation Download Citation

Neil G. Terry, Yizheng Zhu, Matthew Rinehart, and Adam Wax "Optimizing Fourier-domain angle resolved low coherence interferometry for clinical use", Proc. SPIE 7187, Biomedical Applications of Light Scattering III, 71870W (24 February 2009); https://doi.org/10.1117/12.808021

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available