HyperSPECT: a new system for pre-clinical imaging in vivo

Sandra Tibbelin; Peter Nillius; Björn Cederström; Mats Danielsson

doi:10.1117/12.812964

13 March 2009 HyperSPECT: a new system for pre-clinical imaging in vivo

Sandra Tibbelin, Peter Nillius, Björn Cederström, Mats Danielsson

Proceedings Volume 7258, Medical Imaging 2009: Physics of Medical Imaging; 72580X (2009) https://doi.org/10.1117/12.812964
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Imaging in general is becoming increasingly important in the medical science. At the cell level it is possible to label and trace almost individual molecules in vivo to study biochemical reactions using microscopy. In vivo imaging of living organisms is today mainly accomplished by PET, SPECT and fMRI. The problem is that the spatial resolution for realistic image acquisition times is of the order 1-3 mm, which is a serious limitation. We propose a new imaging modality, based on the same principles as SPECT but with drastically improved efficiency and spatial resolution. This is achieved by incorporating a large number of x-ray lenses between the detectors and the object. In current SPECT a pin-hole geometry is standard, involving an unfortunate trade-off between efficiency and spatial resolution, our solution would change this. The agent for radiolabelling is assumed to be ¹²⁵I, with an emission peak at 27 keV, since it is widely used and easy to handle. The large area, photon counting detectors will consist of a columnar CsI scintillator coupled to a CMOS integrated circuit for electronic read-out. Our simulations of the entire system and of the detector indicate that a resolution of 50 μm for the system is possible.

Citation Download Citation

Sandra Tibbelin, Peter Nillius, Björn Cederström, and Mats Danielsson "HyperSPECT: a new system for pre-clinical imaging in vivo", Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72580X (13 March 2009); https://doi.org/10.1117/12.812964

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