Photoacoustic NO detection for asthma diagnostics

Markus Germer; Marcus Wolff; Hermann Harde

doi:10.1117/12.831774

9 July 2009 Photoacoustic NO detection for asthma diagnostics

Markus Germer, Marcus Wolff, Hermann Harde

Proceedings Volume 7371, Novel Optical Instrumentation for Biomedical Applications IV; 73710Q (2009) https://doi.org/10.1117/12.831774
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

Exhaled nitric oxide was of high interest in breath analyses in the past few years. After its first detection in human breath in 1991, numerous publications uncovered the role of NO and its relation to different diseases. A strong relationship between an asthmatic eosinophilic airway inflammation and an increased NO level is medically confirmed. In this study a new photoacoustic detection system for nitric oxide based on a pulsed quantum cascade laser is introduced. The laser's single mode emission provides adequate selectivity to differentiate NO from other molecules in the sample. The demonstrated detection sensitivity allows in principle an application of the new system as diagnostic tool for asthma.

Citation Download Citation

Markus Germer, Marcus Wolff, and Hermann Harde "Photoacoustic NO detection for asthma diagnostics", Proc. SPIE 7371, Novel Optical Instrumentation for Biomedical Applications IV, 73710Q (9 July 2009); https://doi.org/10.1117/12.831774

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