Nanoparticles for contrasting OCT images of skin

Mikhail Kirillin; Pavel Agrba; Vladislav Kamensky; Marina Shirmanova; Marina Sirotkina; Elena Zagainova

doi:10.1117/12.831839

13 July 2009 Nanoparticles for contrasting OCT images of skin

Mikhail Kirillin, Pavel Agrba, Vladislav Kamensky, Marina Shirmanova, Marina Sirotkina, Elena Zagainova

Proceedings Volume 7372, Optical Coherence Tomography and Coherence Techniques IV; 73720V (2009) https://doi.org/10.1117/12.831839
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

Contrasting of skin forming elements in optical coherence tomography (OCT) images after application of silica/gold nanoshells or titanium dioxide nanoparticles in solution is discussed. The study is performed both by Monte Carlo simulations and in vivo on animals. The result show that application of both types of nanoparticles produces contrast increase in the OCT images of skin. The increase in OCT signal level originates from the higher backscattering on nanoparticles compared to that on skin forming elements. The increase of contrast in the OCT images originates from the difference in nanoparticles concentration within different skin constituents. These experimental results are confirmed qualitatively by Monte Carlo simulations based on multilayer skin model.

Citation Download Citation

Mikhail Kirillin, Pavel Agrba, Vladislav Kamensky, Marina Shirmanova, Marina Sirotkina, and Elena Zagainova "Nanoparticles for contrasting OCT images of skin", Proc. SPIE 7372, Optical Coherence Tomography and Coherence Techniques IV, 73720V (13 July 2009); https://doi.org/10.1117/12.831839

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