Tumor PDT-associated immune response: relevance of sphingolipids

Mladen Korbelik; Soroush Merchant; Duska M. Separovic

doi:10.1117/12.842760

11 February 2010 Tumor PDT-associated immune response: relevance of sphingolipids

Mladen Korbelik, Soroush Merchant, Duska M. Separovic

Proceedings Volume 7565, Biophotonics and Immune Responses V; 756502 (2010) https://doi.org/10.1117/12.842760
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Sphingolipids have become recognized as essential effector molecules in signal transduction with involvement in various aspects of cell function and death, immune response and cancer treatment response. Major representatives of sphingolipids family, ceramide, sphingosine and sphingosine-1-phosphate (S1P), have attracted interest in their relevance to tumor response to photodynamic therapy (PDT) because of their roles as enhancers of apoptosis, mediators of cell growth and vasculogenesis, and regulators of immune response. Our recent in vivo studies with mouse tumor models have confirmed that PDT treatment has a pronounced impact on sphingolipid profile in the targeted tumor and that significant advances in therapeutic gain with PDT can be attained by combining this modality with adjuvant treatment with ceramide analog LCL29.

Citation Download Citation

Mladen Korbelik, Soroush Merchant, and Duska M. Separovic "Tumor PDT-associated immune response: relevance of sphingolipids", Proc. SPIE 7565, Biophotonics and Immune Responses V, 756502 (11 February 2010); https://doi.org/10.1117/12.842760

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