Ultra-fast one-micron spectral domain ultra-high-sensitive optical micro-angiography for in-vivo visualization of ocular circulation of human retina and choroid

Lin An; Ruikang K. Wang

doi:10.1117/12.875340

11 February 2011 Ultra-fast one micron spectral domain ultra-high sensitive optical micro-angiography for in vivo visualization of ocular circulation of human retina and choroid

Lin An, Ruikang K. Wang

Author Affiliations +

Proceedings Volume 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV; 78892U (2011) https://doi.org/10.1117/12.875340
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

In this paper, an ultra high speed (92 kHz A-line rate) one micron spectral domain ultra high sensitive optical microangiography system was demonstrated and successfully applied on posterior part of human eye for in vivo visualizing blood perfusions of both retina and choroid. A 1 μm ASE module was utilized as the light source, which could provide much more penetration depth than conventional 800 nm system. Running at 200 frames per second, it would cost ~5 seconds for the system to finish acquiring one 3D data set, which covers ~3×3 mm2 on the retina. Applying the OMAG algorithm onto the slow axis (C-scan direction), our system can extract detailed capillary level ocular perfusion maps for different layers of both retina and choroid. The excellent agreement with the standard text book shows great potential in clinical application.

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Lin An and Ruikang K. Wang "Ultra-fast one micron spectral domain ultra-high sensitive optical micro-angiography for in vivo visualization of ocular circulation of human retina and choroid", Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 78892U (11 February 2011); https://doi.org/10.1117/12.875340

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KEYWORDS

Retina

Capillaries

Blood

Eye

Visualization

In vivo imaging

Imaging systems

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