Use of Mueller polarimetric imaging for the staging of human colon cancer

Angelo Pierangelo; Sandeep Manhas; Abdelali Benali; Maria Rosaria Antonelli; Tatiana Novikova; Pierre Validire; Brice Gayet; Antonello De Martino

doi:10.1117/12.878248

1 March 2011 Use of Mueller polarimetric imaging for the staging of human colon cancer

Angelo Pierangelo, Sandeep Manhas, Abdelali Benali, Maria Rosaria Antonelli, Tatiana Novikova, Pierre Validire, Brice Gayet, Antonello De Martino

Author Affiliations +

Proceedings Volume 7895, Optical Biopsy IX; 78950E (2011) https://doi.org/10.1117/12.878248
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

In this paper we show the results of multi-spectral Mueller Imaging applied to the analysis of human colon cancer in a backscattering configuration with diffuse light illumination. The analyzed sample behaves as a pure depolarizer. The depolarization power, for both healthy and cancerous zones, is lower for linearly than for circularly polarized incident light for all used wavelengths and increases with increasing wavelength. Based on their visual staging and polarimetric responses, we chose specific zones which we correlated to the histology of the corresponding cuts. The histological examination shows that we see a multilayer interaction in both healthy and abnormal zones, if the light penetration depth is sufficient. The measured depolarization depends on several factors: the presence or absence of tumor, the microscopic structure of cancer (ratio between cellular density and stroma), its exophytic (budding) or endophytic (penetrating) nature, its thickness, the degree of cancer penetration in deeper layers and the nature of healthy tissue left under abnormal layers. These results demonstrate that multi-spectral Mueller imaging can provide useful contrasts for the quick staging of human colon cancer ex-vivo, with additional information about cancerous zones with different microscopic structures.

Citation Download Citation

Angelo Pierangelo, Sandeep Manhas, Abdelali Benali, Maria Rosaria Antonelli, Tatiana Novikova, Pierre Validire, Brice Gayet, and Antonello De Martino "Use of Mueller polarimetric imaging for the staging of human colon cancer", Proc. SPIE 7895, Optical Biopsy IX, 78950E (1 March 2011); https://doi.org/10.1117/12.878248

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