Fourier-domain low-coherence interferometry for detection of early colorectal cancer development in the AOM rat model

Francisco E. Robles; Yizheng Zhu; Jin Lee; Sheela Sharma; Adam Wax

doi:10.1117/12.872929

11 February 2011 Fourier domain low coherence interferometry for detection of early colorectal cancer development in the AOM rat model

Francisco E. Robles, Yizheng Zhu, Jin Lee, Sheela Sharma, Adam Wax

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Proceedings Volume 7907, Biomedical Applications of Light Scattering V; 790712 (2011) https://doi.org/10.1117/12.872929
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We present Fourier domain low coherence interferometry (fLCI) applied to the detection of preneoplastic changes in the colon using the ex-vivo azoxymethane (AOM) rat carcinogenesis model. fLCI measures depth resolved spectral oscillations, also known as local oscillations, resulting from coherent fields induced by the scattering of cell nuclei. The depth resolution of fLCI permits nuclear morphology measurements within thick tissues, making the technique sensitive to the earliest stages of precancerous development. To achieve depth resolved spectroscopic analysis, we use the dual window method, which obtains simultaneously high spectral and depth resolution and yields access to the local oscillations. The results show highly statistically significant differences between the AOM-treated and control group samples. Further, the results suggest that fLCI may be used to detect the field effect of carcinogenesis, in addition to identifying specific areas where more advanced neoplastic development has occurred.

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Francisco E. Robles, Yizheng Zhu, Jin Lee, Sheela Sharma, and Adam Wax "Fourier domain low coherence interferometry for detection of early colorectal cancer development in the AOM rat model", Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 790712 (11 February 2011); https://doi.org/10.1117/12.872929

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KEYWORDS

Tissues

Colon

Spectral resolution

Bragg cells

Interferometry

Optical coherence tomography

Spectroscopy

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