Optical coherence tomography for imaging of subpleural alveolar structure using a Fourier domain mode locked laser

Lars Kirsten; Julia Walther; Peter Cimalla; Maria Gaertner; Sven Meissner; Edmund Koch

doi:10.1117/12.889615

1 June 2011 Optical coherence tomography for imaging of subpleural alveolar structure using a Fourier domain mode locked laser

Lars Kirsten, Julia Walther, Peter Cimalla, Maria Gaertner, Sven Meissner, Edmund Koch

Author Affiliations +

Proceedings Volume 8091, Optical Coherence Tomography and Coherence Techniques V; 809118 (2011) https://doi.org/10.1117/12.889615
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

Optical coherence tomography (OCT) is a noninvasive imaging modality generating cross sectional and volumetric images of translucent samples. In Fourier domain OCT (FD OCT), the depth profile is calculated by a fast Fourier transformation of the interference spectrum, providing speed and SNR advantage and thus making FD OCT well suitable in biomedical applications. The interference spectrum can be acquired spectrally resolved in spectral domain OCT or time-resolved in optical frequency domain imaging (OFDI). Since OCT images still suffer from motion artifacts, especially under in vivo conditions, increased depth scan rates are required. Therefor, the principle of Fourier domain mode locking has been presented by R. Huber et al. circumventing the speed limitations of conventional FD OCT systems. In FDML lasers, a long single mode fiber is inserted in the ring resonator of the laser resulting in an optical round trip time of a few microseconds. Sweeping the wavelength synchronously by a tunable Fabry-Perot filter can provide wavelength sweeps with repetition rates up to a few MHz used for OFDI. Imaging of subpleural lung tissue for investigation of lung dynamics and its elastic properties is a further biomedical application demanding high-speed OCT imaging techniques. For the first time, the visualization of subpleural alveolar structures of a rabbit lung is presented by the use of an FDML-based OCT system enabling repetition rates of 49.5 kHz and 122.6 kHz, respectively.

Citation Download Citation

Lars Kirsten, Julia Walther, Peter Cimalla, Maria Gaertner, Sven Meissner, and Edmund Koch "Optical coherence tomography for imaging of subpleural alveolar structure using a Fourier domain mode locked laser", Proc. SPIE 8091, Optical Coherence Tomography and Coherence Techniques V, 809118 (1 June 2011); https://doi.org/10.1117/12.889615

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