4D imaging of embryonic chick hearts by streak-mode Fourier domain optical coherence tomography

Rui Wang; Julie X. Yun; Richard Goodwin; Roger Markwald; Thomas K. Borg; Raymond B. Runyan; Bruce Gao

doi:10.1117/12.907156

17 February 2012 4D imaging of embryonic chick hearts by streak-mode Fourier domain optical coherence tomography

Rui Wang, Julie X. Yun, Richard Goodwin, Roger Markwald, Thomas K. Borg, Raymond B. Runyan, Bruce Gao

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82073V (2012) https://doi.org/10.1117/12.907156
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Recently, we developed the streak-mode Fourier domain optical coherence tomography (OCT) technique in which an area-scan camera is used in a streak-mode to record the OCT spectrum. Here we report the application of this technique to in ovo imaging HH18 embryonic chick hearts with an ultrahigh speed of 1,016,000 axial scans per second. The high-scan rate enables the acquisition of high temporal resolution 2D datasets (1,000 frames per second or 1 ms between frames) and 3D datasets (10 volumes per second), without use of prospective or retrospective gating technique. This marks the first time that the embryonic animal heart has been 4D imaged using a megahertz OCT.

Citation Download Citation

Rui Wang, Julie X. Yun, Richard Goodwin, Roger Markwald, Thomas K. Borg, Raymond B. Runyan, and Bruce Gao "4D imaging of embryonic chick hearts by streak-mode Fourier domain optical coherence tomography", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82073V (17 February 2012); https://doi.org/10.1117/12.907156

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