A rheumatoid arthritis study by Fourier transform infrared spectroscopy

Carolina S. Carvalho; Ana Carla A. Silva; Tatiano J. P. S. Santos; Airton A. Martin; Ana Célia dos Santos Fernandes; Luís E. Andrade; Leandro Raniero

doi:10.1117/12.907117

31 January 2012 A rheumatoid arthritis study by Fourier transform infrared spectroscopy

Carolina S. Carvalho, Ana Carla A. Silva, Tatiano J. P. S. Santos, Airton A. Martin, Ana Célia dos Santos Fernandes, Luís E. Andrade, Leandro Raniero

Author Affiliations +

Proceedings Volume 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry; 821910 (2012) https://doi.org/10.1117/12.907117
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Rheumatoid arthritis is a systemic inflammatory disease of unknown causes and a new methods to identify it in early stages are needed. The main purpose of this work is the biochemical differentiation of sera between normal and RA patients, through the establishment of a statistical method that can be appropriately used for serological analysis. The human sera from 39 healthy donors and 39 rheumatics donors were collected and analyzed by Fourier Transform Infrared Spectroscopy. The results show significant spectral variations with p<0.05 in regions corresponding to protein, lipids and immunoglobulins. The technique of latex particles, coated with human IgG and monoclonal anti-CRP by indirect agglutination known as FR and CRP, was performed to confirm possible false-negative results within the groups, facilitating the statistical interpretation and validation of the technique.

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Carolina S. Carvalho, Ana Carla A. Silva, Tatiano J. P. S. Santos, Airton A. Martin, Ana Célia dos Santos Fernandes, Luís E. Andrade, and Leandro Raniero "A rheumatoid arthritis study by Fourier transform infrared spectroscopy", Proc. SPIE 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 821910 (31 January 2012); https://doi.org/10.1117/12.907117

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