Development of a new method for cervical cancer cells determination using light scattering spectrum

Yan Yang; Rongfeng Jia; Qiyong Sun; Kun Song; Beihua Kong; Xuantao Su

doi:10.1117/12.2001241

24 October 2012 Development of a new method for cervical cancer cells determination using light scattering spectrum

Yan Yang, Rongfeng Jia, Qiyong Sun, Kun Song, Beihua Kong, Xuantao Su

Proceedings Volume 8412, Photonics North 2012; 841205 (2012) https://doi.org/10.1117/12.2001241
Event: Photonics North 2012, 2012, Montréal, Canada

Abstract

Conventional methods for cervical cancer screening usually employ microscopic observations that may require fluorescence labeling of the cells, which could be time-consuming and expensive. Development of a novel method for cervical cancer cells determination in a rapid, label-free manner may significantly improve the cervical cancer screening technique. Here two-dimensional (2D) light scattering patterns are obtained from yeast cells on a CMOS chip, where laser light is used to excite single cells via fiber-coupling under a microscope. Good agreements between the experimental and Mie theory simulation results convey that 2D light scattering patterns from cervical cancer cells may be obtained upon the apparatus developed here. Mie theory simulations on simplified normal and cancerous cervical cells show that side scattering spectrum may be used for cervical cancer cells screening. Future experiments further convincing the 2D light scattering method proposed here may bring up a powerful technique that has profound applications in cervical cancer cell determination.

Citation Download Citation

Yan Yang, Rongfeng Jia, Qiyong Sun, Kun Song, Beihua Kong, and Xuantao Su "Development of a new method for cervical cancer cells determination using light scattering spectrum", Proc. SPIE 8412, Photonics North 2012, 841205 (24 October 2012); https://doi.org/10.1117/12.2001241

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