Optical coherence tomography demonstrates differential epidermal
thinning of human forearm volar skin after 2 weeks application of a
topical corticosteroid vs a non-steroidal anti-inflammatory alternative

Zenghai Lu; Joseph Boadi; Simon Danby; Michael Cork; Stephen J. Matcher

doi:10.1117/12.2006104

8 March 2013 Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

Zenghai Lu, Joseph Boadi, Simon Danby, Michael Cork, Stephen J. Matcher

Author Affiliations +

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 85650C (2013) https://doi.org/10.1117/12.2006104
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

The effects on skin of two commercially available topical creams for the treatment of eczema are quantitatively studied using optical coherence tomography. An archetypal corticosteroid (Betamethasone valerate) is compared with a nonsteroidal anti-inflammatory drug (Tacrolimus monohydrate) via left/right comparisons of the epidermal thickness of volar forearm skin on selected volunteers, at baseline and after 14 days of treatment. In 3 of 4 subjects we confirmed previous observations that corticosteroids produce pronounced physical thinning of the epidermis over timescales of a few weeks. In 3 of 4 subjects we further found that Tacrolimus produced no change in epidermal thickness. In one of 4 subjects we found evidence that the epidermis was actually thickened following treatment using Tacrolimus.

Citation Download Citation

Zenghai Lu, Joseph Boadi, Simon Danby, Michael Cork, and Stephen J. Matcher "Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85650C (8 March 2013); https://doi.org/10.1117/12.2006104

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Optical coherence tomography

Skin

Image resolution

Backscatter

Collagen

Confocal microscopy

Diagnostics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years