Validation of diffuse optical tomography using a bi-functional optical-MRI contrast agent and a hybrid MRI-DOT system

Alex T. Luk; Yuting Lin; Brian Grimmond; Anup Sood; Egidijus E. Uzgiris; Orhan Nalcioglu; Gultekin Gulsen

doi:10.1117/12.2003606

13 March 2013 Validation of diffuse optical tomography using a bi-functional optical-MRI contrast agent and a hybrid MRI-DOT system

Alex T. Luk, Yuting Lin, Brian Grimmond, Anup Sood, Egidijus E. Uzgiris, Orhan Nalcioglu, Gultekin Gulsen

Author Affiliations +

Proceedings Volume 8574, Multimodal Biomedical Imaging VIII; 85740K (2013) https://doi.org/10.1117/12.2003606
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Since diffuse optical tomography (DOT) is a low spatial resolution modality, it is desirable to validate its quantitative accuracy with another well-established imaging modality, such as magnetic resonance imaging (MRI). In this work, we have used a polymer based bi-functional MRI-optical contrast agent (Gd-DTPA-polylysine-IR800) in collaboration with GE Global Research. This multi-modality contrast agent provided not only co-localization but also the same kinetics, to cross-validate two imaging modalities. Bi-functional agents are injected to the rats and pharmacokinetics at the bladder are recovered using both optical and MR imaging. DOT results are validated using MRI results as "gold standard"

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Alex T. Luk, Yuting Lin, Brian Grimmond, Anup Sood, Egidijus E. Uzgiris, Orhan Nalcioglu, and Gultekin Gulsen "Validation of diffuse optical tomography using a bi-functional optical-MRI contrast agent and a hybrid MRI-DOT system", Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 85740K (13 March 2013); https://doi.org/10.1117/12.2003606

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