Reconstruction of cerebral hemodynamics with dynamic contrast-enhanced time-resolved near-infrared measurements before and during ischemia

Jonathan T. Elliott; Mamadou Diop; Laura B. Morrison; Ting-Yim Lee; Keith St. Lawrence

doi:10.1117/12.2005128

25 March 2013 Reconstruction of cerebral hemodynamics with dynamic contrast-enhanced time-resolved near-infrared measurements before and during ischemia

Jonathan T. Elliott, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, Keith St. Lawrence

Author Affiliations +

Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85780A (2013) https://doi.org/10.1117/12.2005128
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We present a dynamic contrast-enhanced near-infrared (DCE-NIR) technique that is capable of non-invasive quantification of cerebral hemodynamics in adults. The challenge of removing extracerebral contamination is overcome through the use of multi-distance time-resolved DCE-NIR combined with the kinetic deconvolution optical reconstruction (KDOR) analytical method. As proof-of-principle, cerebral blood flow, cerebral blood volume and mean transit time recovered with DCE-NIR are compared with CT perfusion values in an adult pig during normocapnia, hypocapnia, and ischemia. Measurements of blood flow acquired with DCE-NIR were compared against concomitant measurements using CT Perfusion.

Citation Download Citation

Jonathan T. Elliott, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, and Keith St. Lawrence "Reconstruction of cerebral hemodynamics with dynamic contrast-enhanced time-resolved near-infrared measurements before and during ischemia", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780A (25 March 2013); https://doi.org/10.1117/12.2005128

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