3D laser optoacoustic ultrasonic imaging system for preclinical research

Sergey A. Ermilov; André Conjusteau; Travis Hernandez; Richard Su; Vyacheslav Nadvoretskiy; Dmitri Tsyboulski; Fatima Anis; Mark A. Anastasio; Alexander A. Oraevsky

doi:10.1117/12.2008811

4 March 2013 3D laser optoacoustic ultrasonic imaging system for preclinical research

Sergey A. Ermilov, André Conjusteau, Travis Hernandez, Richard Su, Vyacheslav Nadvoretskiy, Dmitri Tsyboulski, Fatima Anis, Mark A. Anastasio, Alexander A. Oraevsky

Author Affiliations +

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 85810N (2013) https://doi.org/10.1117/12.2008811
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical or other type of biomedical research. The system (LOUIS-3DM) combines a multi-wavelength optoacoustic and ultrawide-band laser ultrasound tomographies to obtain coregistered maps of tissue optical absorption and acoustic properties, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distribution of optoacoustic contrast agents (carbon nanotubes, metal plasmonic nanoparticles, etc.).

Citation Download Citation

Sergey A. Ermilov, André Conjusteau, Travis Hernandez, Richard Su, Vyacheslav Nadvoretskiy, Dmitri Tsyboulski, Fatima Anis, Mark A. Anastasio, and Alexander A. Oraevsky "3D laser optoacoustic ultrasonic imaging system for preclinical research", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85810N (4 March 2013); https://doi.org/10.1117/12.2008811

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