Sensing cocaine in saliva with infrared laser spectroscopy

Kerstin M.-C. Hans; Matthias Müller; Michele Gianella; Ph. Wägli; Markus W. Sigrist

doi:10.1117/12.2003615

22 February 2013 Sensing cocaine in saliva with infrared laser spectroscopy

Kerstin M.-C. Hans, Matthias Müller, Michele Gianella, Ph. Wägli, Markus W. Sigrist

Proceedings Volume 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics; 85910F (2013) https://doi.org/10.1117/12.2003615
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Increasing numbers of accidents caused by drivers under the influence of drugs, raise drug tests to worldwide interest. We developed a one-step extraction technique for cocaine in saliva and analyzed reference samples with laser spectroscopy employing two different schemes. The first is based on attenuated total reflection (ATR), which is applied to dried samples. The second scheme uses transmission measurements for the analysis of liquid samples. ATR spectroscopy achieved a limit of detection (LOD) of 3μg/ml. The LOD for the transmission approach in liquid samples is < 10 μg/ml. These LODs are realistic as such concentration ranges are encountered in the saliva of drug users after the administration of a single dose of cocaine. An improved stabilization of the set-up should lower the limit of detection significantly.

Citation Download Citation

Kerstin M.-C. Hans, Matthias Müller, Michele Gianella, Ph. Wägli, and Markus W. Sigrist "Sensing cocaine in saliva with infrared laser spectroscopy", Proc. SPIE 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 85910F (22 February 2013); https://doi.org/10.1117/12.2003615

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available