Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging

L. Sudheendra; Gautom K. Das; C. Li; Simon R. Cherry; Ian M. Kennedy

doi:10.1117/12.2005250

21 February 2013 Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging

L. Sudheendra, Gautom K. Das, C. Li, Simon R. Cherry, Ian M. Kennedy

Proceedings Volume 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V; 85960D (2013) https://doi.org/10.1117/12.2005250
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd³⁺ and Eu³⁺compositions in lanthanide fluorides to optimize the emission from Eu³⁺ upon X-ray excitation. The optimum concentration of Eu³⁺ that produced the most intense emission in NaGdF₄ was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce³⁺) in NaGdF₄:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF₄:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.

Citation Download Citation

L. Sudheendra, Gautom K. Das, C. Li, Simon R. Cherry, and Ian M. Kennedy "Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging", Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 85960D (21 February 2013); https://doi.org/10.1117/12.2005250

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