Visual analysis and dynamical control of phosphoproteomic networks

Anke Meyer-Bäse; Robert Görke; Marc Lobbes; Mark R. Emmett; Carol L. Nilsson

doi:10.1117/12.2019381

29 May 2013 Visual analysis and dynamical control of phosphoproteomic networks

Anke Meyer-Bäse, Robert Görke, Marc Lobbes, Mark R. Emmett, Carol L. Nilsson

Proceedings Volume 8750, Independent Component Analyses, Compressive Sampling, Wavelets, Neural Net, Biosystems, and Nanoengineering XI; 87500X (2013) https://doi.org/10.1117/12.2019381
Event: SPIE Defense, Security, and Sensing, 2013, Baltimore, Maryland, United States

Abstract

This paper presents novel graph algorithms and modern control solutions applied to the graph networks resulting from specific experiments to discover disease-related pathways and drug targets in glioma cancer stem cells (GSCs). The theoretical framework applies to many other high-throughput data from experiments relevant to a variety of diseases. In addition to developing novel graph and control networks to predict therapeutic targets, these algorithms will provide biochemists with techniques to identify more metabolic regions and biological pathways for complex diseases, and design and test novel therapeutic solutions.

Citation Download Citation

Anke Meyer-Bäse, Robert Görke, Marc Lobbes, Mark R. Emmett, and Carol L. Nilsson "Visual analysis and dynamical control of phosphoproteomic networks", Proc. SPIE 8750, Independent Component Analyses, Compressive Sampling, Wavelets, Neural Net, Biosystems, and Nanoengineering XI, 87500X (29 May 2013); https://doi.org/10.1117/12.2019381

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