Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography

Yong Huang; Dedi Tong; Shan Zhu; Lehao Wu; Zuhaib Ibrahim; WP Andrew Lee; Gerald Brandacher; Jin U. Kang

doi:10.1117/12.2041975

4 March 2014 Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography

Yong Huang, Dedi Tong, Shan Zhu, Lehao Wu, Zuhaib Ibrahim, WP Andrew Lee, Gerald Brandacher, Jin U. Kang

Proceedings Volume 8934, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII; 893425 (2014) https://doi.org/10.1117/12.2041975
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Vascular and microvascular anastomosis are critical components of reconstructive microsurgery, vascular surgery and transplant surgery. Imaging modality that provides immediate, real-time in-depth view and 3D structure and flow information of the surgical site can be a great valuable tool for the surgeon to evaluate surgical outcome following both conventional and innovative anastomosis techniques, thus potentially increase the surgical success rate. Microvascular anastomosis for vessels with outer diameter smaller than 1.0 mm is extremely challenging and effective evaluation of the outcome is very difficult if not impossible using computed tomography (CT) angiograms, magnetic resonance (MR) angiograms and ultrasound Doppler. Optical coherence tomography (OCT) is a non-invasive high-resolution (micron level), high-speed, 3D imaging modality that has been adopted widely in biomedical and clinical applications. Phaseresolved Doppler OCT that explores the phase information of OCT signals has been shown to be capable of characterizing dynamic blood flow clinically. In this work, we explore the capability of Fourier domain Doppler OCT as an evaluation tool to detect commonly encountered post-operative complications that will cause surgical failure and to confirm positive result with surgeon’s observation. Both suture and cuff based techniques were evaluated on the femoral artery and vein in the rodent model.

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Yong Huang, Dedi Tong, Shan Zhu, Lehao Wu, Zuhaib Ibrahim, WP Andrew Lee, Gerald Brandacher, and Jin U. Kang "Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography", Proc. SPIE 8934, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII, 893425 (4 March 2014); https://doi.org/10.1117/12.2041975

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KEYWORDS

Optical coherence tomography

Surgery

Blood circulation

Doppler tomography

Arteries

Cameras

Veins

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