Microencapsulation of multiple components by compound-fluidic electro-flow focusing

Chuansheng Yin; Ting Si; Peng Gao; Fan Lei; Ronald X. Xu

doi:10.1117/12.2041068

17 February 2014 Microencapsulation of multiple components by compound-fluidic electro-flow focusing

Chuansheng Yin, Ting Si, Peng Gao, Fan Lei, Ronald X. Xu

Proceedings Volume 8937, Multimodal Biomedical Imaging IX; 89370M (2014) https://doi.org/10.1117/12.2041068
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Microcapsules with multiple components inside a biodegradable shell are of great significance in various applications such as biomedicine, biochemistry, sustained drug delivery and image-guided therapy. Here we report a compoundfluidic electro-flow focusing (CFEFF) process that has the potential to one-step envelope multiple drugs and imaging agents separately into a single microcapsule. In this method, a compound needle is assembled by embedding two parallel thin inner needles into a relatively large outer needle. Two kinds of core fluids flow through the inner needles separately and the shell fluid flows through the outer needle. Under the action of aerodynamic and electric driving forces, stable cone-jet configurations can be obtained, resulting in multilayered microcapsules after the breakup of the compound liquid jet because of flow instability. The feasibility and effectiveness of using this CFEFF method to encapsulate multiple components into one shell is verified experimentally. The effects of various process parameters on the morphology and size of the microcapsules are further studied.

Citation Download Citation

Chuansheng Yin, Ting Si, Peng Gao, Fan Lei, and Ronald X. Xu "Microencapsulation of multiple components by compound-fluidic electro-flow focusing", Proc. SPIE 8937, Multimodal Biomedical Imaging IX, 89370M (17 February 2014); https://doi.org/10.1117/12.2041068

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