Effects of laser immunotherapy on tumor microenvironment

Joseph T. Acquaviva III; Ethan W. Wood; Aamr Hasanjee; Wei R. Chen; Melville B. Vaughan

doi:10.1117/12.2040680

27 February 2014 Effects of laser immunotherapy on tumor microenvironment

Joseph T. Acquaviva III, Ethan W. Wood, Aamr Hasanjee, Wei R. Chen, Melville B. Vaughan

Proceedings Volume 8944, Biophotonics and Immune Responses IX; 894407 (2014) https://doi.org/10.1117/12.2040680
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

The microenvironments of tumors are involved in a complex and reciprocal dialog with surrounding cancer cells. Any novel treatment must consider the impact of the therapy on the microenvironment. Recently, clinical trials with laser immunotherapy (LIT) have proven to effectively treat patients with late-stage, metastatic breast cancer and melanoma. LIT is the synergistic combination of phototherapy (laser irradiation) and immunological stimulation. One prominent cell type found in the tumor stroma is the fibroblast. Fibroblast cells can secrete different growth factors and extracellular matrix modifying molecules. Furthermore, fibroblast cells found in the tumor stroma often express alpha smooth muscle actin. These particular fibroblasts are coined cancer-associated fibroblast cells (CAFs). CAFs are known to facilitate the malignant progression of tumors. A collagen lattice assay with human fibroblast cells is used to elucidate the effects LIT has on the microenvironment of tumors. Changes in the contraction of the lattice, the differentiation of the fibroblast cells, as well as the proliferation of the fibroblast cells will be determined.

Citation Download Citation

Joseph T. Acquaviva III, Ethan W. Wood, Aamr Hasanjee, Wei R. Chen, and Melville B. Vaughan "Effects of laser immunotherapy on tumor microenvironment", Proc. SPIE 8944, Biophotonics and Immune Responses IX, 894407 (27 February 2014); https://doi.org/10.1117/12.2040680

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