Ultrabright and bleaching-resistant hybrid gold nanoparticles for confocal and two-photon fluorecence imaging

P. L. Baldeck; J. Navarro; G. Micouin; A.-M. Gabudean; F. Lerouge; C. Monnerau; F. Chaput; C. Andraud; S. Parola

doi:10.1117/12.2039479

7 March 2014 Ultrabright and bleaching-resistant hybrid gold nanoparticles for confocal and two-photon fluorecence imaging

P. L. Baldeck, J. Navarro, G. Micouin, A.-M. Gabudean, F. Lerouge, C. Monnerau, F. Chaput, C. Andraud, S. Parola

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Proceedings Volume 8956, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI; 89560T (2014) https://doi.org/10.1117/12.2039479
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We review our work on hybrid gold nanoparticles that are optimized for their bright fluorescence and photobleaching resistance. Our first goal in using gold nanoparticles is to load a large density of photoactive molecules onto a biocompatible nanoplatform. Our second goal is to optimize the molecule-gold nanoparticle interaction to improve the photoactive properties, in particular their photobleaching resistance. In this project gold nanoparticles have typical dimensions in the 50-100 nm that are suitable for in vivo imaging and photodynamic therapy. Their geometrical shapes include nanoshell, spheres, rods, bipyramids and stars.

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P. L. Baldeck, J. Navarro, G. Micouin, A.-M. Gabudean, F. Lerouge, C. Monnerau, F. Chaput, C. Andraud, and S. Parola "Ultrabright and bleaching-resistant hybrid gold nanoparticles for confocal and two-photon fluorecence imaging", Proc. SPIE 8956, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI, 89560T (7 March 2014); https://doi.org/10.1117/12.2039479

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KEYWORDS

Gold

Nanoparticles

Luminescence

Resistance

Optical spheres

Molecules

Plasmons

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