In-situ detection of DNA hybridization with a microfiber Bragg grating biosensor

Dandan Sun; Tuan Guo; Xiaodong Xie; Yang Ran; Yunyun Huang; Bai-Ou Guan

doi:10.1117/12.2059433

2 June 2014 In-situ detection of DNA hybridization with a microfiber Bragg grating biosensor

Dandan Sun, Tuan Guo, Xiaodong Xie, Yang Ran, Yunyun Huang, Bai-Ou Guan

Proceedings Volume 9157, 23rd International Conference on Optical Fibre Sensors; 91574Z (2014) https://doi.org/10.1117/12.2059433
Event: OFS2014 23rd International Conference on Optical Fiber Sensors, 2014, Santander, Spain

Abstract

Microfiber Bragg gratings (mFBGs) can be used as cost-effective and relatively simple-to-implement biosensors for monitoring DNA interactions in situ. The sensors are functionalized by a monolayer of poly-L-lysine (PLL) with the specific molecular recognition probe DNA sequences to bind with high specificity to a given target. By recording the wavelength seperation between the two resonant peaks of a single mFBG, the mFBG biosensor is capable of detecting the presence of specific target DNA in situ.

Citation Download Citation

Dandan Sun, Tuan Guo, Xiaodong Xie, Yang Ran, Yunyun Huang, and Bai-Ou Guan "In-situ detection of DNA hybridization with a microfiber Bragg grating biosensor", Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 91574Z (2 June 2014); https://doi.org/10.1117/12.2059433

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