Preparation of multifunctional upconversion nanoconstruct for in vitro and in vivo imaging and photodynamic therapy induced by near-infrared light

Deyan Yin; Shanshan Huang; Ying Zhang; Yueqing Gu

doi:10.1117/12.2068692

17 September 2014 Preparation of multifunctional upconversion nanoconstruct for in vitro and in vivo imaging and photodynamic therapy induced by near-infrared light

Deyan Yin, Shanshan Huang, Ying Zhang, Yueqing Gu

Author Affiliations +

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 923018 (2014) https://doi.org/10.1117/12.2068692
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Upconversion nanoparticles (UCNPs) have attracted much attention as novel contrast agents for low-background biomedical imaging and potential photosensitizer carriers for photodynamic therapy (PDT) in deep tissues. In this work, firstly we synthesized NaYF₄:Yb³⁺,Tm³⁺@NaYF₄:Yb³⁺,Er³⁺ core-shell structured UCNPs with multiple emission peaks (e.g. 480, 539, 654 and 800 nm) by a seeded growth approach. By coating folate-modified amphiphilic chitosan (FASOC) on UCNPs, the as-prepared UCNPs were favorably endowed with good water solubility and the enhanced tumor-selectivity to cancer cells that overexpressed folate receptor. Then, water-insoluble photosensitizer zinc(II) phthalocyanine (ZnPc) was loaded into the FASOC-UCNPs via hydrophobic interactions for potential near-infrared light induced photodynamic therapy (PDT). Our results indicate that the multifunctional FASOC-UCNP-ZnPc nanoconstruct has efficient NIR-to-NIR upconversion luminescence and PDT abilities, which could be potentially employed as a theranostic platform for cancer treatment.

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Deyan Yin, Shanshan Huang, Ying Zhang, and Yueqing Gu "Preparation of multifunctional upconversion nanoconstruct for in vitro and in vivo imaging and photodynamic therapy induced by near-infrared light ", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923018 (17 September 2014); https://doi.org/10.1117/12.2068692

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KEYWORDS

Photodynamic therapy

Luminescence

Nanoparticles

In vivo imaging

Near infrared

Upconversion

Imaging systems

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