Multifunctional iron oxide nanoparticles for biomedical applications

M. Bloemen; Carla Denis; Thomas Van Stappen; L. De Meester; N. Geukens; A. Gils; T. Verbiest

doi:10.1117/12.2076120

12 March 2015 Multifunctional iron oxide nanoparticles for biomedical applications

M. Bloemen, Carla Denis, Thomas Van Stappen, L. De Meester, N. Geukens, A. Gils, T. Verbiest

Proceedings Volume 9338, Colloidal Nanoparticles for Biomedical Applications X; 933816 (2015) https://doi.org/10.1117/12.2076120
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Multifunctional nanoparticles have attracted a lot of attention since they can combine interesting properties like magnetism, fluorescence or plasmonic effects. As a core material, iron oxide nanoparticles have been the subject of intensive research. These cost-effective and non-toxic particles are used nowadays in many applications. We developed a heterobifunctional PEG ligand that can be used to introduce functional groups (carboxylic acids) onto the surface of the NP. Via click chemistry, a siloxane functionality was added to this ligand, for a subsequent covalent ligand exchange reaction. The functionalized nanoparticles have an excellent colloidal stability in complex environments like buffers and serum or plasma. Antibodies were coupled to the introduced carboxylic acids and these NP-antibody bioconjugates were brought into contact with Legionella bacteria for magnetic separation experiments.

Citation Download Citation

M. Bloemen, Carla Denis, Thomas Van Stappen, L. De Meester, N. Geukens, A. Gils, and T. Verbiest "Multifunctional iron oxide nanoparticles for biomedical applications", Proc. SPIE 9338, Colloidal Nanoparticles for Biomedical Applications X, 933816 (12 March 2015); https://doi.org/10.1117/12.2076120

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