Detection of Alzheimer's disease using group lasso SVM-based region selection

Zhuo Sun; Yong Fan; Boudewijn P. F. Lelieveldt M.D.; Martijn van de Giessen

doi:10.1117/12.2081368

20 March 2015 Detection of Alzheimer's disease using group lasso SVM-based region selection

Zhuo Sun, Yong Fan, Boudewijn P. F. Lelieveldt M.D., Martijn van de Giessen

Proceedings Volume 9414, Medical Imaging 2015: Computer-Aided Diagnosis; 941414 (2015) https://doi.org/10.1117/12.2081368
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

Alzheimer's disease (AD) is one of the most frequent forms of dementia and an increasing challenging public health problem. In the last two decades, structural magnetic resonance imaging (MRI) has shown potential in distinguishing patients with Alzheimer's disease and elderly controls (CN). To obtain AD-specific biomarkers, previous research used either statistical testing to find statistically significant different regions between the two clinical groups, or ℓ₁ sparse learning to select isolated features in the image domain. In this paper, we propose a new framework that uses structural MRI to simultaneously distinguish the two clinical groups and find the bio-markers of AD, using a group lasso support vector machine (SVM). The group lasso term (mixed ℓ₁- ℓ₂ norm) introduces anatomical information from the image domain into the feature domain, such that the resulting set of selected voxels are more meaningful than the ℓ₁ sparse SVM. Because of large inter-structure size variation, we introduce a group specific normalization factor to deal with the structure size bias. Experiments have been performed on a well-designed AD vs. CN dataset¹ to validate our method. Comparing to the ℓ₁ sparse SVM approach, our method achieved better classification performance and a more meaningful biomarker selection. When we vary the training set, the selected regions by our method were more stable than the ℓ₁ sparse SVM. Classification experiments showed that our group normalization lead to higher classification accuracy with fewer selected regions than the non-normalized method. Comparing to the state-of-art AD vs. CN classification methods, our approach not only obtains a high accuracy with the same dataset, but more importantly, we simultaneously find the brain anatomies that are closely related to the disease.

Citation Download Citation

Zhuo Sun, Yong Fan, Boudewijn P. F. Lelieveldt M.D., and Martijn van de Giessen "Detection of Alzheimer's disease using group lasso SVM-based region selection", Proc. SPIE 9414, Medical Imaging 2015: Computer-Aided Diagnosis, 941414 (20 March 2015); https://doi.org/10.1117/12.2081368

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