Real time monitoring of Pb2+-induced formation of G-quadruplex DNA with LPFG sensor

Z. Bagheri; H. Latifi; B. Ranjbar; M. I. Zibaii; E. Behroodi

doi:10.1117/12.2193767

28 September 2015 Real time monitoring of Pb²⁺-induced formation of G-quadruplex DNA with LPFG sensor

Z. Bagheri, H. Latifi, B. Ranjbar, M. I. Zibaii, E. Behroodi

Proceedings Volume 9634, 24th International Conference on Optical Fibre Sensors; 96344E (2015) https://doi.org/10.1117/12.2193767
Event: International Conference on Optical Fibre Sensors (OFS24), 2015, Curitiba, Brazil

Abstract

In this paper the potential of real time monitoring of AS1411 Guanine-quadruplex folding by using long period fiber grating (LPFG) biosensor was described. AS1411 ss-DNA folds into parallel bimolecular quadruplex in solution containing metal ions. While immobilized AS1411 folds, molecular crowding of sensing area will increase and cause change the refractive index (RI) around the sensor. In addition RI change is absolutely dependent on G-quadruplex factor concentration.

Citation Download Citation

Z. Bagheri, H. Latifi, B. Ranjbar, M. I. Zibaii, and E. Behroodi "Real time monitoring of Pb²⁺-induced formation of G-quadruplex DNA with LPFG sensor", Proc. SPIE 9634, 24th International Conference on Optical Fibre Sensors, 96344E (28 September 2015); https://doi.org/10.1117/12.2193767

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