Optical coherence tomography for detection of compound action potential in Xenopus Laevis sciatic nerve

Francesca Troiani; Konstantin Nikolic; Timothy G. Constandinou

doi:10.1117/12.2209335

9 March 2016 Optical coherence tomography for detection of compound action potential in Xenopus Laevis sciatic nerve

Francesca Troiani, Konstantin Nikolic, Timothy G. Constandinou

Proceedings Volume 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation; 96901F (2016) https://doi.org/10.1117/12.2209335
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Due to optical coherence tomography (OCT) high spatial and temporal resolution, this technique could be used to observe the quick changes in the refractive index that accompany action potential. In this study we explore the use of time domain Optical Coherence Tomography (TD-OCT) for real time action potential detection in ex vivo Xenopus Laevis sciatic nerve. TD-OCT is the easiest and less expensive OCT technique and, if successful in detecting real time action potential, it could be used for low cost monitoring devices. A theoretical investigation into the order of magnitude of the signals detected by a TD-OCT setup is provided by this work. A linear dependence between the refractive index and the intensity changes is observed and the minimum SNR for which the setup could work is found to be SNR = 2 x 10⁴.

Conference Presentation

Citation Download Citation

Francesca Troiani, Konstantin Nikolic, and Timothy G. Constandinou "Optical coherence tomography for detection of compound action potential in Xenopus Laevis sciatic nerve", Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96901F (9 March 2016); https://doi.org/10.1117/12.2209335

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